RenardV1, Main, Exploration, bibRecord, 000863

Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2

Identifieur interne : 000863 ( Main/Exploration ); précédent : 000862; suivant : 000864

Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2

Auteurs : T. Mülller [Allemagne] ; T. Selhorst [Allemagne] ; J. Burow [Allemagne] ; A. Schameitat [Allemagne] ; A. Vos [Allemagne]

Source :

Developments in biologicals [ 1424-6074 ] ; 2006.

RBID : Pascal:07-0049429

Descripteurs français

Pascal (Inist)
- Vulpes vulpes, Lyssavirus, Antigénicité, Vaccin, Efficacité, Réaction croisée, Immunsérum, Réservoir, Immunoprotection, European bat lyssavirus, Nyctereutes procyonoides.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Antigenicity, Antiserum, Cross reaction, Efficiency, Immunoprotection, Lyssavirus, Reservoir, Vaccine, Vulpes vulpes.

Abstract

For the first time, the effectiveness of oral rabies vaccines against European Bat Lyssaviruses Type 1 (EBLV-1) and Type 2 (EBLV-2) by means of cross-neutralization assays was investigated. Sera from orally vaccinated red foxes (Vulpes vulpes) and raccoon dogs (Nyctereutes procyonoides) with the Street Alabama Dufferin (SAD) B19 and SAD P5/88 live-modified vaccine viruses were used to study the cross reactive antigenicity against CVS-11 (genotype 1), EBLV-1 (genotype 5) and EBLV-2 (genotype 6). For comparison, similar crossneutralization assays with sera from EBLV-1 and EBLV-2 infected ferrets (Mustela putorius furo) and/or foxes were conducted. Sera from animals vaccinated with the two oral rabies vaccines were reactive against CVS-11 (homologous virus), EBLV-1 and EBLV-2 (heterologous virus). There was a positive relationship among the virus neutralising antibody titres (VNA); high VNA titres against CVS-11 also resulted in high VNA titres against each EBLV, whereas in general, the VNA-titres obtained with homologous virus were statistically higher than those with the heterologous virus except for SAD P5/88 vaccinated raccoon dogs. No significant difference was found between EBLV-1 and EBLV-2 VNA titres. A similar trend was observed when the results of the cross-neutralization data of the foxes and ferrets inoculated i.m. with EBLV-1 and/or EBLV-2 was analysed. Based on the similarity of the EBLV-VNA titres obtained in our study questions were raised on whether the genetic distance of genotype 5 & 6 within phylogroup 1 really does reflect their antigenetic characteristics or whether this is a feature of attenuated live vaccine viruses. This broad cross protection, however, demonstrated that the representatives of attenuated SAD strains of oral rabies vaccines currently used in Germany are most likely able to protect the reservoir species, red fox and raccoon dog, against EBLV-1 and EBLV-2 infection.

Affiliations:

Allemagne

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000041
to stream PascalFrancis, to step Curation: 000047
to stream PascalFrancis, to step Checkpoint: 000044
to stream Main, to step Merge: 000886
to stream Main, to step Curation: 000863

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2</title>
<author><name sortKey="Mulller, T" sort="Mulller, T" uniqKey="Mulller T" first="T." last="Mülller">T. Mülller</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Selhorst, T" sort="Selhorst, T" uniqKey="Selhorst T" first="T." last="Selhorst">T. Selhorst</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Burow, J" sort="Burow, J" uniqKey="Burow J" first="J." last="Burow">J. Burow</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schameitat, A" sort="Schameitat, A" uniqKey="Schameitat A" first="A." last="Schameitat">A. Schameitat</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Impstoffwerk Dessau Tornau GmbH (IDT)</s1>
<s2>Rosslau</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Rosslau</wicri:noRegion>
<wicri:noRegion>Impstoffwerk Dessau Tornau GmbH (IDT)</wicri:noRegion>
<wicri:noRegion>Impstoffwerk Dessau Tornau GmbH (IDT)</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0049429</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 07-0049429 INIST</idno>
<idno type="RBID">Pascal:07-0049429</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000041</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000047</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000044</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000044</idno>
<idno type="wicri:doubleKey">1424-6074:2006:Mulller T:cross:reactive:antigenicity</idno>
<idno type="wicri:Area/Main/Merge">000886</idno>
<idno type="wicri:Area/Main/Curation">000863</idno>
<idno type="wicri:Area/Main/Exploration">000863</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2</title>
<author><name sortKey="Mulller, T" sort="Mulller, T" uniqKey="Mulller T" first="T." last="Mülller">T. Mülller</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Selhorst, T" sort="Selhorst, T" uniqKey="Selhorst T" first="T." last="Selhorst">T. Selhorst</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Burow, J" sort="Burow, J" uniqKey="Burow J" first="J." last="Burow">J. Burow</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schameitat, A" sort="Schameitat, A" uniqKey="Schameitat A" first="A." last="Schameitat">A. Schameitat</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-lnstitut, Federal Research Institute for Animal Health, WHC Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHC Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Impstoffwerk Dessau Tornau GmbH (IDT)</s1>
<s2>Rosslau</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Rosslau</wicri:noRegion>
<wicri:noRegion>Impstoffwerk Dessau Tornau GmbH (IDT)</wicri:noRegion>
<wicri:noRegion>Impstoffwerk Dessau Tornau GmbH (IDT)</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Developments in biologicals</title>
<title level="j" type="abbreviated">Dev. biol.</title>
<idno type="ISSN">1424-6074</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Developments in biologicals</title>
<title level="j" type="abbreviated">Dev. biol.</title>
<idno type="ISSN">1424-6074</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigenicity</term>
<term>Antiserum</term>
<term>Cross reaction</term>
<term>Efficiency</term>
<term>Immunoprotection</term>
<term>Lyssavirus</term>
<term>Reservoir</term>
<term>Vaccine</term>
<term>Vulpes vulpes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Vulpes vulpes</term>
<term>Lyssavirus</term>
<term>Antigénicité</term>
<term>Vaccin</term>
<term>Efficacité</term>
<term>Réaction croisée</term>
<term>Immunsérum</term>
<term>Réservoir</term>
<term>Immunoprotection</term>
<term>European bat lyssavirus</term>
<term>Nyctereutes procyonoides</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">For the first time, the effectiveness of oral rabies vaccines against European Bat Lyssaviruses Type 1 (EBLV-1) and Type 2 (EBLV-2) by means of cross-neutralization assays was investigated. Sera from orally vaccinated red foxes (Vulpes vulpes) and raccoon dogs (Nyctereutes procyonoides) with the Street Alabama Dufferin (SAD) B19 and SAD P5/88 live-modified vaccine viruses were used to study the cross reactive antigenicity against CVS-11 (genotype 1), EBLV-1 (genotype 5) and EBLV-2 (genotype 6). For comparison, similar crossneutralization assays with sera from EBLV-1 and EBLV-2 infected ferrets (Mustela putorius furo) and/or foxes were conducted. Sera from animals vaccinated with the two oral rabies vaccines were reactive against CVS-11 (homologous virus), EBLV-1 and EBLV-2 (heterologous virus). There was a positive relationship among the virus neutralising antibody titres (VNA); high VNA titres against CVS-11 also resulted in high VNA titres against each EBLV, whereas in general, the VNA-titres obtained with homologous virus were statistically higher than those with the heterologous virus except for SAD P5/88 vaccinated raccoon dogs. No significant difference was found between EBLV-1 and EBLV-2 VNA titres. A similar trend was observed when the results of the cross-neutralization data of the foxes and ferrets inoculated i.m. with EBLV-1 and/or EBLV-2 was analysed. Based on the similarity of the EBLV-VNA titres obtained in our study questions were raised on whether the genetic distance of genotype 5 & 6 within phylogroup 1 really does reflect their antigenetic characteristics or whether this is a feature of attenuated live vaccine viruses. This broad cross protection, however, demonstrated that the representatives of attenuated SAD strains of oral rabies vaccines currently used in Germany are most likely able to protect the reservoir species, red fox and raccoon dog, against EBLV-1 and EBLV-2 infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Mulller, T" sort="Mulller, T" uniqKey="Mulller T" first="T." last="Mülller">T. Mülller</name>
</noRegion>
<name sortKey="Burow, J" sort="Burow, J" uniqKey="Burow J" first="J." last="Burow">J. Burow</name>
<name sortKey="Schameitat, A" sort="Schameitat, A" uniqKey="Schameitat A" first="A." last="Schameitat">A. Schameitat</name>
<name sortKey="Selhorst, T" sort="Selhorst, T" uniqKey="Selhorst T" first="T." last="Selhorst">T. Selhorst</name>
<name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/RenardV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000863 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000863 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Bois
   |area=    RenardV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:07-0049429
   |texte=   Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2
}}

This area was generated with Dilib version V0.6.27.
Data generation: Tue Mar 28 00:55:51 2017. Site generation: Thu Jan 4 16:57:14 2024

	Serveur d'exploration sur le renard
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le renard

Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2

Cross reactive antigenicity in orally vaccinated foxes and raccoon dogs against european bat lyssavirus Type 1 and 2

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri